Successful epliepsy treatment with purified cannabinoid, without THC, posted on the UCSF official website article on January 05, 2016:
“Better treatment for children with uncontrolled seizures is desperately needed,” said Maria Roberta Cilio, MD, PhD, senior author and director of research at the UCSF Pediatric Epilepsy Center. “It’s important to get seizure control at any age, but in children, uncontrolled seizures may impact brain and neurocognitive development, which can have an extraordinary effect on quality of life and contribute to progressive cognitive impairment.”
The researchers evaluated 162 children and young adults across 11 independent epilepsy centers in the U.S. All of the children were treated with Epidiolex, a purified cannabinoid that comes in a liquid form containing no tetrahydrocannabinol (THC), the psychotropic component in cannabis, over a 12-week period. The results showed a median 36.5 percent reduction in monthly motor seizures, with a median monthly frequency of motor seizures falling from 30 motor seizures a month to 15.8 over the course of the 12 week trial.
The study was published in the Dec. 23, 2015 issue of The Lancet Neurology.
The patients in the trial were all between the ages of one and 30 with intractable epilepsies shown to be resistant to many if not all of the antiepileptic treatments, including drugs and a ketogenic diet. This includes children with Dravet syndrome, a rare genetic disorder that manifests in early childhood with frequent, disabling seizures often occurring daily and numbering into the hundreds, as well as profound cognitive and social deficits.
“This trial is pioneering a new treatment for children with the most severe epilepsies, for whom nothing else works,” said Cilio. “This is just the first step. This open label study found that CBD both reduces the frequency of seizures and has an adequate safety profile in children and young adults. Randomized controlled trials are the next step to characterize the true efficacy and safety profile of this promising compound.”
The study article is an update from the ABC 7 News article: CANNABIS-BASED DRUG HELPS KIDS WITH SEVERE SEIZURES (with video) - May 4, 2015
Similar results/stories in other news:
Synthetic cannabis medical trial to treat Victorian children with severe epilepsy - February 2, 2016
Epileptic girl who moved to Colorado for medical marijuana has dramatically improved, parents say (with video) - May 19, 2015
NORCAL FATHER TREATS SON'S EPILEPSY WITH MARIJUANA - December 7, 2012